Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease : update on clinical, diagnostic, and management aspects
Articolo
Data di Pubblicazione:
2017
Citazione:
Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease : update on clinical, diagnostic, and management aspects / I. Di Donato, S. Bianchi, N. De Stefano, M. Dichgans, M.T. Dotti, M. Duering, E. Jouvent, A.D. Korczyn, S.A.J. Lesnik-Oberstein, A. Malandrini, H.S. Markus, L. Pantoni, S. Penco, A. Rufa, O. Sinanović, D. Stojanov, A. Federico. - In: BMC MEDICINE. - ISSN 1741-7015. - 15:1(2017 Feb 24), pp. 41.1-41.12.
Abstract:
Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common and best known monogenic small vessel disease. Here, we review the clinical, neuroimaging, neuropathological, genetic, and therapeutic aspects based on the most relevant articles published between 1994 and 2016 and on the personal experience of the authors, all directly involved in CADASIL research and care. We conclude with some suggestions that may help in the clinical practice and management of these patients.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
CADASIL; Genetics; NOTCH 3; Small vessel disease; Vascular dementia; CADASIL; Cerebral Small Vessel Diseases; Humans
Elenco autori:
I. Di Donato, S. Bianchi, N. De Stefano, M. Dichgans, M.T. Dotti, M. Duering, E. Jouvent, A.D. Korczyn, S.A.J. Lesnik-Oberstein, A. Malandrini, H.S. Markus, L. Pantoni, S. Penco, A. Rufa, O. Sinanović, D. Stojanov, A. Federico
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