Effect of Attention Training in Mild Cognitive Impairment Patients with Subcortical Vascular Changes : the RehAtt Study
Articolo
Data di Pubblicazione:
2017
Citazione:
Effect of Attention Training in Mild Cognitive Impairment Patients with Subcortical Vascular Changes : the RehAtt Study / L. Pantoni, A. Poggesi, S. Diciotti, R. Valenti, S. Orsolini, E. Della Rocca, D. Inzitari, M. Mascalchi, E. Salvadori. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 60:2(2017), pp. 615-624. [10.3233/JAD-170428]
Abstract:
BACKGROUND AND OBJECTIVE:
Mild cognitive impairment (MCI) patients with small vessel disease (SVD) are at high dementia risk. We tested the effects of cognitive rehabilitation in these patients using the Attention Process Training-II (APT-II) program in a single-blinded, randomized clinical trial.
METHODS:
Patients were randomized to APT-II or standard care and evaluated at baseline, 6, and 12 months with functional, quality of life, cognitive tests, and resting state functional MRI (rsfMRI).
RESULTS:
Forty-six patients were enrolled and 43 (mean±SD age 75.1±6.8) completed the study. No change was seen in functionality and quality of life between treated and non-treated patients. However, the Rey Auditory-Verbal Learning Test immediate recall showed a significant improvement in treated compared to non-treated group (change score 6 versus 12 months: 1.8±4.9 and -1.4±3.8, p = 0.021; baseline versus 12 months: 3.8±6.1 and 0.2±4.4, p = 0.032). A higher proportion of treated patients had stable/better evaluation compared to non-treated group on Visual search test (6 versus 12 months: 95% versus 71%, p = 0.038) and Rey-Osterrieth Complex Figure copy (6 versus 12 months: 95% versus 67%, p = 0.027). RsfMRI, performed in a subsample, showed that the difference between follow-up and baseline in synchronization of activity in cerebellar areas was significantly greater in treated than in non-treated patients.
CONCLUSION:
We were unable to show a significant effect in quality of life or functional status in treated patients with MCI and SVD. However, APT-II produces some beneficial effects in focused attention and working memory and seems to increase activity in brain circuits involved in cognitive processes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cerebrovascular disorders; clinical trial; cognitive dysfunction; functional magnetic resonance imaging; rehabilitation; Clinical Psychology; Geriatrics and Gerontology; Psychiatry and Mental Health
Elenco autori:
L. Pantoni, A. Poggesi, S. Diciotti, R. Valenti, S. Orsolini, E. Della Rocca, D. Inzitari, M. Mascalchi, E. Salvadori
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