Cryotherapy for low risk prostate cancer, oncological and functional medium term outcomes : A three center prospective study
Articolo
Data di Pubblicazione:
2017
Citazione:
Cryotherapy for low risk prostate cancer, oncological and functional medium term outcomes : A three center prospective study / V.C. Lucan, F. Lugnani, S. Buttice, E. Sener, C. Netsch, M. Talso, F. Cantiello, R. Pappalardo, C. Magno. - In: ARCHIVIO ITALIANO DI UROLOGIA ANDROLOGIA. - ISSN 1124-3562. - 89:2(2017), pp. 97-101.
Abstract:
Objectives: Analyze the oncologic and functional outcomes in patients affected by low risk prostate cancer underwent prostate cryotherapy. Materiasl and methods: It's a prospective tricentric study of 434 patients treated with prostate cryoablation for low risk prostate cancer. By low risk we refer to the D'Amico's risk classification. Two cycles of freezing/thawing are run for each patient following the technique described by Onik. Results: For the 434 patients, the median age was 66 years with a standard deviation of ± 6.68, the average PSA was 6.17 ng/d/L, the median 5.55 with a standard deviation of ± 2.13, the mean prostate volume was 35.59 cc, the median 34.00 cc, with a standard deviation of ± 7.89. Biochemical failure occurred in 67 patients (15.4%). Pre-operative erectile function in men was distributed as follows: severe in 95 patients (19.2%), moderate in 95 (19.2%), medium-moderate in 180 (36.4%), mild in 92 (18.6%), with no dysfunction in 32 (6.5%) patients. Post-operative erectile function, measured 1 month after cryotherapy, was distributed as follows: severe in 321 (65%) patients, moderate in 69 (14%), medium-moderate in 79 (16%), mild in 23 (4.7%), and no dysfunction in only 2 patients (0.4%). Post-operative erectile function after 3 months was distributed as follows: severe in 233 (47.2%) patients, moderate in 66 (13.4%), medium-moderate in 122 (24.7%), mild in 65 (13.2%), and no dysfunction in 8 patients (1.6%). Urinary incontinence was present in 21 patients (4.8%) after 3 months while it dropped to 13 patients (2.9%) after 6 months. Conclusions: Cryotherapy in the treatment of prostate cancer remains a viable alternative. The availability of new cryoprobes and the use of new diagnostic means such as fusion magnetic resonance will make this more precise and more effective method.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
focal therapy; low risk prostate cancer; minimally invasive treatment; prostate cryotherapy; aged; erectile dysfunction; humans; male; penile erection; prospective studies; prostatic neoplasms; recovery of function; risk assessment; time factors; treatment outcome; cryotherapy; urology
Elenco autori:
V.C. Lucan, F. Lugnani, S. Buttice, E. Sener, C. Netsch, M. Talso, F. Cantiello, R. Pappalardo, C. Magno
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