Evaluation of inter-observer variability according to RECIST 1.1 and its influence on response classification in CT measurement of liver metastases
Articolo
Data di Pubblicazione:
2017
Citazione:
Evaluation of inter-observer variability according to RECIST 1.1 and its influence on response classification in CT measurement of liver metastases / M. Bellomi, F. De Piano, E. Ancona, A. Ferla Lodigiani, G. Curigliano, S. Raimondi, L. Preda. - In: EUROPEAN JOURNAL OF RADIOLOGY. - ISSN 0720-048X. - 95(2017 Oct), pp. 96-101. [10.1016/j.ejrad.2017.08.001]
Abstract:
Objective The aim of this study is the evaluation of inter-observer variability in the measurement of liver metastases according to RECIST and its influence on response classification. Patients and methods A total of 100 radiologists measured liver target lesions, on pre- and post-chemotherapy CT scans of three patients. Each observer filled out a questionnaire about his personal and work features. The evaluations of a well experienced radiologist, considered as âthe gold standardâ , were compared to those taken by the observers. The percentage of the observers in agreement with the reviewer, in terms of the response category and in terms of inter-observer variability, was calculated for each patient. Results The percentage of the inter-observer agreement was elevated. Most of the observers in agreement with the reviewer were senior radiologists, while those who disagreed were junior radiologist, but this result did not reach a statistical significance. More than 30% of observers disagreed with the reviewer at least in one of the three cases. Conclusions RECIST measurements are reproducible on a large and heterogeneous population of radiologists. Age and expertise of the radiologist remain the most critical factors: this suggests a revision by well-experienced radiologists in clinical trials.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Computed tomography; Inter-observer variability; Oncology; RECIST 1.1; Radiology, Nuclear Medicine and Imaging
Elenco autori:
M. Bellomi, F. De Piano, E. Ancona, A. Ferla Lodigiani, G. Curigliano, S. Raimondi, L. Preda
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