High sensitivity cardiac troponin T in patients not having an acute coronary syndrome: results from the TRAPID-AMI study
Articolo
Data di Pubblicazione:
2017
Citazione:
High sensitivity cardiac troponin T in patients not having an acute coronary syndrome: results from the TRAPID-AMI study / R. Nowak, C. Mueller, E. Giannitsis, M. Christ, J. Ordonez-Llanos, C. Defilippi, J. Mccord, R. Body, M. Panteghini, T. Jernberg, M. Plebani, F. Verschuren, J.K. French, R. Christenson, G. Jacobsen, C. Dinkel, B. Lindahl. - In: BIOMARKERS. - ISSN 1354-750X. - 22:8(2017), pp. 709-714. [10.1080/1354750X.2017.1334154]
Abstract:
Purpose: To describe the baseline, 1 hr and delta high sensitivity cardiac troponin (hs-cTnT) values in patients with suspected acute myocardial infarction (AMI) but without a final acute coronary syndrome (ACS) diagnosis.
Materials and methods: hs-cTnT assay for RAPID rule out of acute myocardial infarction (TRAPID-AMI) was a prospective diagnostic trial that enrolled emergency department (ED) patients with suspected AMI. Final patient diagnoses were adjudicated by a clinical events committee and subjects placed in different clinical groups: AMI, unstable angina, non-ACS cardiac, non-cardiac and unknown origin. The
baseline, 1 hr and delta hs-cTnT values were analysed in the 902 non-ACS patients.
Results: Amongst the 1282 studied the patient groups were 213 (17%) AMI, 167 (13%) unstable angina, 113 (9%) non-ACS cardiac, 288 (22%) non-cardiac and 501 (39%) unknown origin. The hs-cTnT values in the non-cardiac and unknown origin groups were combined. The median hs-cTnT values (ng/L) were higher (p < 0.001) in the non-ACS cardiac compared to the non-cardiac/unknown origin
group at baseline (11.8, <5) and 1 hr (12.3, <5). Their negative predictive values were 0.955 (baseline) and 0.954 (1 hr) for predicting non-ACS cardiac versus non-cardiac/unknown origin diagnoses.
Conclusions: Hs-cTnT may help predict whether non-ACS ED patients have a final non-ACS cardiac or non-cardiac/unknown origin diagnoses.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
High sensitivity troponin; non ACS patients; emergency department
Elenco autori:
R. Nowak, C. Mueller, E. Giannitsis, M. Christ, J. Ordonez-Llanos, C. Defilippi, J. Mccord, R. Body, M. Panteghini, T. Jernberg, M. Plebani, F. Verschuren, J.K. French, R. Christenson, G. Jacobsen, C. Dinkel, B. Lindahl
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