Painful neuropathy in subclinical hypothyroidism : Clinical and neuropathological recovery after hormone replacement therapy
Articolo
Data di Pubblicazione:
2009
Citazione:
Painful neuropathy in subclinical hypothyroidism : Clinical and neuropathological recovery after hormone replacement therapy / P. Penza, R. Lombardi, F. Camozzi, C. Ciano, G. Lauria. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-1874. - 30:2(2009 Apr), pp. 149-151.
Abstract:
We describe a 60-year-old woman complaining of severe burning feet for 3 months. A neurological examination showed absent Achilles tendon reflexes; nerve conduction study demonstrated mild sensory neuropathy, and skin biopsy revealed a length-dependent loss of intraepidermal nerve fibres. Haematological exams demonstrated a subclinical hypothyroidism and hormone replacement therapy was started. Conversely, symptomatic treatments for neuropathic pain were withdrawn after few days because of side effects. During the following months, thyroid function recovered, and the patient experienced a progressive decrease of neuropathic pain intensity. At 6- and 12-month follow-ups, nerve conduction study and clinical examination were normal, whereas skin biopsy demonstrated a complete reinnervation of the epidermis. Subclinical hypothyroidism is a possible cause of sensory neuropathy and hormone replacement therapy can prompt nerve regeneration.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
nerve conduction study; nerve regeneration; painful neuropathy; skin biopsy; thyroid; biopsy; estrogens; female; foot; hormone replacement therapy; humans; hypothyroidism; middle aged; nerve regeneration; neural conduction; neuralgia; pain measurement; peripheral nervous system diseases; recovery of function; sensory receptor cells; thyroid function tests; thyroid gland; treatment outcome; neurology (clinical); psychiatry and mental health; 2708
Elenco autori:
P. Penza, R. Lombardi, F. Camozzi, C. Ciano, G. Lauria
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