Beneficial effects of PKF275-055, a novel, selective, orally bioavailable, long-acting dipeptidyl peptidase IV inhibitor in streptozotocin-induced diabetic peripheral neuropathy
Articolo
Data di Pubblicazione:
2012
Citazione:
Beneficial effects of PKF275-055, a novel, selective, orally bioavailable, long-acting dipeptidyl peptidase IV inhibitor in streptozotocin-induced diabetic peripheral neuropathy / R. Bianchi, I. Cervellini, C. Porretta-serapiglia, N. Oggioni, B. Burkey, P. Ghezzi, G. Cavaletti, G. LAURIA PINTER. - In: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. - ISSN 0022-3565. - 340:1(2012 Jan), pp. 64-72.
Abstract:
1-[(2-adamantyl)amino]acetyl-2-cyano-(S)-pyrrolidine, monohydrochloride (PKF275-055), a vildagliptin analog, is a novel, selective, potent, orally bioavailable, and long-acting dipeptidyl peptidase IV inhibitor. We studied the effect of PKF275-055 administration on the prevention, protection, and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat. PKF275-055 improved body and muscle weight. Oral glucose tolerance tests showed a marked improvement in glucose metabolism under all treatment schedules. When tested in prevention and protection experiments, PKF275-055 completely averted the decrease of Na +/K +-ATPase activity and partially counteracted the nerve conduction velocity (NCV) deficit observed in untreated diabetic rats but had no effects on abnormal mechanical and thermal sensitivity. When used in a therapeutic setting, PKF275- 055 induced a significant correction in the alteration in Na +,K +- ATPase activity and NCV present in untreated diabetics. Diabetic rats developed mechanical hyperalgesia within 2 weeks after streptozotocin injection and exhibited significantly longer thermal response latencies. It is noteworthy that PKF275-055 treatment restored mechanical sensitivity thresholds by approximately 50% (p < 0.01) and progressively improved the alteration in thermal responsiveness. In conclusion, PKF275-055 showed an anabolic effect, improved oral glucose tolerance, and counteracted the alterations in Na +,K +-ATPase activity, NCV, and nociceptive thresholds in diabetic rats. The present data support a potential therapeutic effect of PKF275-055 in the treatment of rodent diabetic neuropathy.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
adamantane; animals; behavior, animal; body weight; diabetes mellitus, experimental; diabetic neuropathies; dipeptidyl-peptidase IV inhibitors; disease progression; dose-response relationship, drug; drinking; eating; glucagon-like peptide 1; glucose tolerance test; male; neural conduction; nitriles; pain threshold; peripheral nervous system diseases; pyrrolidines; rats; rats, Sprague-Dawley; sodium-potassium-exchanging ATPase; pharmacology; molecular medicine
Elenco autori:
R. Bianchi, I. Cervellini, C. Porretta-serapiglia, N. Oggioni, B. Burkey, P. Ghezzi, G. Cavaletti, G. LAURIA PINTER
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