Data di Pubblicazione:
2012
Citazione:
Small fibre neuropathy / G. Lauria, I..S..J. Merkies, C..G. Faber. - In: CURRENT OPINION IN NEUROLOGY. - ISSN 1350-7540. - 25:5(2012 Oct), pp. 542-549.
Abstract:
Purpose of Review: This review summarizes the most recent advances in classification, diagnostic assessment, and treatment of small fibre neuropathy (SFN). Recent Findings: Clinically based diagnostic criteria for SFN have been proposed and reliably supported by the recent availability of age-adjusted and sex-adjusted normative values for intraepidermal nerve fibre density. Apart from skin biopsy, corneal confocal microscopy and nociceptive evoked potentials have been implemented to investigate SFN of different causes, and correlated with skin biopsy findings, especially in diabetic patients. The association between SFN and several metabolic and immune-mediated systemic diseases, and drugs toxic to this subset of peripheral nerve fibres has been reported. An exciting advance has been the identification of gain-of-function mutations in the SCN9A gene encoding for Nav1.7 sodium channel in patients with SFN, leading to the definition of a new genetic channelopathy. Summary: SFN represents a distinct condition encountered in patients with different acquired and genetic disorders. The recent improved definition of clinical and skin biopsy criteria allows clinicians to reliably meet the diagnosis, identify the underlying cause, and prescribe appropriate treatments. This meaningful approach permits the correct management of patients in clinical practice and the design of symptomatic and disease-modifying clinical trials. © 2012 Wolters Kluwer Health | Lippincott Williams & Wilkins.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
corneal microscopy; intraepidermal nerve fibres; painful neuropathy; skin biopsy; small fibre neuropathy; Animals; Biopsy; Humans; Nerve Fibers; Neuralgia; Neurologic Examination; Pain Measurement; Peripheral Nervous System Diseases; Neurology (clinical); Neurology
Elenco autori:
G. Lauria, I..S..J. Merkies, C..G. Faber
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