Intra-epidermal nerve fibers density and nociception in EPO-treated type 1 diabetic rats with peripheral neuropathy
Capitolo
Data di Pubblicazione:
2013
Citazione:
Intra-epidermal nerve fibers density and nociception in EPO-treated type 1 diabetic rats with peripheral neuropathy / R. Bianchi, R. Lombardi, C. PORRETTA SERAPIGLIA, G. LAURIA PINTER (METHODS IN MOLECULAR BIOLOGY). - In: Tissue-Protective Cytokines : Methods and Protocols / [a cura di] P. Ghezzi, A. Cerami. - [s.l] : Humana Press Inc., 2013. - ISBN 9781627033077. - pp. 197-211 [10.1007/978-1-62703-308-4_13]
Abstract:
Small-diameter nervefibers, which subserve nociception, can be affected early in peripheral neuropathies, although their injury may not be detectable by routine neurophysiologic tests. On the other hand, skin biopsy has proved to be a reliable tool to examine nonmyelinated nervefibers, as assessed by the quantification of intra-epidermal nervefiber (IENF) density not only along with the degenerative process but, noteworthy, IENF density could be very helpful in evaluating drug efficacy such as erythropoietin (EPO) treatment.
Tipologia IRIS:
03 - Contributo in volume
Keywords:
Diabetes; Diabetic neuropathy; Epidermal nerve fibers; Erythropoietin; PGP 9.5; Skin; Animals; Diabetes Mellitus, Type 1; Erythropoietin; Male; Nerve Fibers; Nociception; Peripheral Nervous System Diseases; Rats; Rats, Sprague-Dawley; Molecular Biology; Genetics
Elenco autori:
R. Bianchi, R. Lombardi, C. PORRETTA SERAPIGLIA, G. LAURIA PINTER
Link alla scheda completa:
Titolo del libro:
Tissue-Protective Cytokines : Methods and Protocols