Non-paraneoplastic voltage-gated calcium channels antibody-mediated cerebellar ataxia responsive to IVIG treatment
Articolo
Data di Pubblicazione:
2014
Citazione:
Non-paraneoplastic voltage-gated calcium channels antibody-mediated cerebellar ataxia responsive to IVIG treatment / A. Rigamonti, G. LAURIA PINTER, L. Stanzani, V. Mantero, F. Andreetta, A. Salmaggi. - In: JOURNAL OF THE NEUROLOGICAL SCIENCES. - ISSN 0022-510X. - 336:1-2(2014 Jan 15), pp. 169-170. [10.1016/j.jns.2013.10.031]
Abstract:
Non-paraneoplastic cerebellar ataxia associated with voltage-gated calcium channel (VGCC) antibodies is a rare entity with only few cases reported in literature. We describe a 60 year-old man with subacute cerebellar ataxia and subclinical Lambert-Eaton myasthenic syndrome (LEMS) in whom VGCC antibodies were detected at high titer in serum and cerebrospinal fluid. Screening for underlying malignancies was negative. Intravenous immunoglobulin treatment led to the improvement of clinical picture and reduction of serum antibody titer over a 13-month follow-up period. We emphasize that VGCC antibodies should be included in the diagnostic work-up of patients with subacute cerebellar ataxia and that treatment with IVIG can improve the clinical picture and prevent disability. © 2013 Elsevier B.V. All rights reserved.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
antibodies; cerebellar ataxia; eaton-lambert myasthenic syndrome; immuno-mediated ataxia; intravenous immunoglobulin; voltage-gated calcium channels; autoantibodies; calcium channels; cerebellar ataxia; diagnosis, differential; humans; immunoglobulins, intravenous; lambert-eaton myasthenic syndrome; male; middle aged; treatment outcome; neurology; neurology (clinical)
Elenco autori:
A. Rigamonti, G. LAURIA PINTER, L. Stanzani, V. Mantero, F. Andreetta, A. Salmaggi
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