ANALYSIS OF GENOMIC DATA IN RUMINANT SPECIES FOR PARENTAGE, PRODUCT TRACING AND POPULATION STRUCTURE STUDIES
Tesi di Dottorato
Data di Pubblicazione:
2018
Citazione:
ANALYSIS OF GENOMIC DATA IN RUMINANT SPECIES FOR PARENTAGE, PRODUCT TRACING AND POPULATION STRUCTURE STUDIES / A. Talenti ; tutor.F. Gandolfi, P. Crepaldi. DIPARTIMENTO DI MEDICINA VETERINARIA, 2018 Mar 02. 30. ciclo, Anno Accademico 2017. [10.13130/talenti-andrea_phd2018-03-02].
Abstract:
The availability of genomic and high performance computing
technologies gave access to new approaches and methods to exploit the
high number of genetic information provided, even in livestock species.
These new tools can be used to unveil the relationships between different
populations or individuals, to understand the genetic background of breeds,
to define the genetic architecture of phenotypes or pathologies and to
detect selection signatures that shaped the cattle, sheep and goat reared
today.
In this context, these technologies may provide breeders and
breeders’ associations with new tools that may be used in livestock
management. In fact, the estimation of genomic parentage among
individuals can help in defining the least related animals in case of identical
values of additive parentage and detect errors in pedigree declarations as
well. Moreover, since DNA is immutable within animal life but very
polymorphic between individuals, these tools may be of help in the
definition of the breed or the individual of origin, improving food safety.
In this thesis, I faced the complexity of genomic data in ruminant
species, focusing in particular on goats. I reported three studies with distinct
aims: i) study the signatures of selection in 369 animals of 16 Italian
populations, and then focusing on the Valdostana goat breed which
presents a breed-specific broad signature of selection in chromosome 7; ii)
define a new method to develop panels of SNPs for parentage assessment
that could be applied on species with unreliable genomic assembly; and iii)
study the selection signatures in 929 animals of 41 Pakistani and Italian goat
populations associated with a specific pigmentation pattern, the roan,
detecting a candidate gene important in understanding the coat color
genetics in goats and which could be also used as a marker for traceability
of breeds that carry this peculiar phenotypic pattern.
Tipologia IRIS:
Tesi di dottorato
Elenco autori:
A. Talenti
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