Data di Pubblicazione:
2017
Citazione:
A pharmacokinetic study of GC-1 delivery using a nanochannel membrane device / C.S. Filgueira, A. Ballerini, E. Nicolov, C.Y.X. Chua, P. Jain, Z.W. Smith, A.L. Gilbert, F. Scaglione, A. Grattoni. - In: NANOMEDICINE. - ISSN 1549-9634. - 13:5(2017), pp. 1739-1744.
Abstract:
This study demonstrated a nanochannel membrane device (NMD) for controlled and sustained release of GC-1 in rats, in the context of the treatment of metabolic syndrome. Release profiles were established in vitro both with and without 5% labrasol for over 2 months. In vivo pharmacokinetic evaluation showed effective GC-1 plasma concentrations, which resulted in significant reductions in body weight after just one week of treatment when compared to the NMD releasing vehicle only (PBS). We also provided evidence that rats treated with NMD-GC-1 present sub-active thyroids and clear differences in the morphology of the epithelium and follicles as compared to the controls, while the heart showed changes in weight. Moreover, body temperatures remained stable throughout treatment, and glucose, pancreatic islet size, and liver histology appeared similar between the treated and control groups. Prolonged constant administration of GC-1 from the NMD proved to be a valid strategy to facilitate weight loss.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
GC-1 (Sobetirome); Nanochannel membrane device (NMD); Pharmacokinetic; Thyroid gland; Weight loss; Medicine (miscellaneous); Bioengineering; Biomedical Engineering; Molecular Medicine; Materials Science (all); 3003
Elenco autori:
C.S. Filgueira, A. Ballerini, E. Nicolov, C.Y.X. Chua, P. Jain, Z.W. Smith, A.L. Gilbert, F. Scaglione, A. Grattoni
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