Data di Pubblicazione:
2007
Citazione:
Kynurenic acid in honey from arboreal plants : MS and NMR evidence / G. Beretta, E. Caneva, R. Maffei Facino. - In: PLANTA MEDICA. - ISSN 0032-0943. - 73:15(2007), pp. 1592-1595.
Abstract:
KYNA, a Trp metabolite, shows neuroprotective activity against excitotoxic amino acids by antagonizing the NMDA receptor (glycine, glutamate). Here we report the identification of KYNA by a combination of ESI-MS/MS and 1D- and 2D-NMR analyses in honey varieties of arboreal origin. KYNA are absent in single-flower honeys from herbal flowers. These different distribution patterns might possibly involve an indirect plant defence mechanism against fungal pathogens and herbivorous parasites, ever-present on wild trees. The presence of KYNA in honey may explain its pain-relieving effects reported in the literature. The substance, acting in concert with honey flavonoids (COX-2 inhibitors), by antagonizing the NMDA receptor may contribute to the antinociceptive effect of honey. Moreover, kynureninates, owing to their antimicrobial properties, can favour the successful outcome of wounds and burns
Tipologia IRIS:
01 - Articolo su periodico
Elenco autori:
G. Beretta, E. Caneva, R. Maffei Facino
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