An olfactory reference syndrome successfully treated by aripiprazole augmentation of antidepressant therapy
Articolo
Data di Pubblicazione:
2008
Citazione:
An olfactory reference syndrome successfully treated by aripiprazole augmentation of antidepressant therapy / R. Muffatti, S. Scarone, O. Gambini. - In: COGNITIVE AND BEHAVIORAL NEUROLOGY. - ISSN 1543-3633. - 21:4(2008), pp. 258-260.
Abstract:
Abstract:
Objective: To describe a case of a 65-year-old woman with persistent olfactory hallucination and delusional self-reference, successfully treated by aripiprazole augmentation of antidepressant therapy.
Background: Olfactory reference syndrome is a nosologic entity, which has been assimilated to various Diagnostic and Statistical Manual of Mental Disorder-IV-text revision codified diseases and several pharmacologic treatments have been proposed without a constant clinical response.
Method: Psychiatric, neurologic, neuropsychologic, imaging, and electroencephalogram data are reported.
Results: The patient showed a significant improvement with aripiprazole.
Conclusions: We propose a pathophysiologic model of olfactory reference syndrome to explain the good response of our patient to aripiprazole. We hypothesize a disruption in the top-down regulation of the orbitofrontal cortex on the primary olfactory cortex and the olfactory bulb at the basis of the illness. Aripiprazole acting as a partial agonist of dopamine D2 receptors in the olfactory bulb compensates for the lack of modulation in this site, restoring the correct processing of olfactory information.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Aripiprazole; Olfactory bulb; Olfactory hallucination; Olfactory reference syndrome; Orbitofrontal cortex
Elenco autori:
R. Muffatti, S. Scarone, O. Gambini
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