Data di Pubblicazione:
2017
Citazione:
Structural vaccinology for melioidosis vaccine design and immunodiagnostics / A. Gori, M. Bolognesi, G. Colombo, L.J. Gourlay. - In: CURRENT TROPICAL MEDICINE REPORTS. - ISSN 2196-3045. - 4:3(2017 Sep 01), pp. 103-110. [10.1007/s40475-017-0117-3]
Abstract:
Purpose of Review
Spurred by the successful application of structural vaccinology to other challenging bacterial and viral pathogens, we review the possibility of exploiting 3D structure computational-based recombinant antigen engineering strategies for the development of a protective melioidosis vaccine.
Recent Findings
Structure-based epitope design approaches in the melioidosis field are preliminary and applied essentially by one research network. By combining Burkholderia pseudomallei antigen 3D structures and in silico epitope discovery methods, a panel of synthetic epitope peptides were designed and tested for their B and T cell stimulatory activities. Several peptides were found to be serodiagnostic for B. pseudomallei infection and two elicited bactericidal antibodies.
Summary
A significant amount of B. pseudomallei antigen structures, epitopes, and immunological data is available. Future challenges will be to test all available B. pseudomallei epitopes, focusing on combing multiple B/T cell epitopes onto a single scaffold to generate components, stimulating both arms of the immune system.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
melioidosis; vaccines; epitope design; structural vaccinology; B. pseudomallei; antigens
Elenco autori:
A. Gori, M. Bolognesi, G. Colombo, L.J. Gourlay
Link alla scheda completa:
Link al Full Text: