Data di Pubblicazione:
2008
Citazione:
The vascular endothelial growth factor +405G>C polymorphism in endometriosis / D. Gentilini, E. Somigliana, P. Viganò, M. Vignali, M. Busacca, A.M. Di Blasio. - In: HUMAN REPRODUCTION. - ISSN 0268-1161. - 23:1(2008 Jan), pp. 211-215.
Abstract:
BACKGROUND: Vascular endothelial growth factor (VEGF) is a potent stimulus of
angiogenesis potentially contributing to the pathogenesis of endometriosis. The
aim of this study was to investigate the potential association between the single
nucleotide polymorphism +405G>C of the VEGF gene with the risk of endometriosis,
for the first time in the Caucasian population. METHODS: The polymorphism +405G>C
of the VEGF gene was examined in n = 203 Italian women affected by endometriosis
and in n = 140 women without laparoscopic evidence of the disease. All the women
were genotyped by PCR-restriction fragment length polymorphism from venous blood
samples. We then performed a meta-analysis including results from the present
study and from the two previously published studies on this topic. RESULTS: The
distribution of the three different genotypes significantly differed between
women with and without the disease (P = 0.03). The odds ratio (95% confidence
interval) for endometriosis in women carrying the C allele was 1.8 (1.2-2.8). The
Breslow-Day test revealed statistically significant heterogeneity among the
studies performed so far thus indicating inconsistency among studies and
excluding the possibility of obtaining a common estimation of the effect.
CONCLUSIONS: Results obtained herein are in keeping with those obtained
previously and support a role for the +405G>C VEGF polymorphism in endometriosis
development, although a further, larger study is required to confirm our
findings. However, this effect may depend on the population studied. Ethnicity
and the characteristics of endometriosis are likely to influence this
association.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
405G>C; Endometriosis; Polymorphism; Vascular endothelial growth factor
Elenco autori:
D. Gentilini, E. Somigliana, P. Viganò, M. Vignali, M. Busacca, A.M. Di Blasio
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