Functional network connectivity abnormalities in multiple sclerosis : correlations with disability and cognitive impairment
Articolo
Data di Pubblicazione:
2018
Citazione:
Functional network connectivity abnormalities in multiple sclerosis : correlations with disability and cognitive impairment / M. Rocca, P. Valsasina, V. Leavitt, M. Rodegher, M. Radaelli, G. Riccitelli, V. Martinelli, F. Martinelli-Boneschi, A. Falini, G. Comi, M. Filippi. - In: MULTIPLE SCLEROSIS. - ISSN 1352-4585. - 24:4(2018 Apr), pp. 459-471. [10.1177/1352458517699875]
Abstract:
Objective: To investigate resting state (RS) functional connectivity (FC) abnormalities within the principal
brain networks in a large cohort of multiple sclerosis (MS) patients, to define the trajectory of FC
changes over disease stages and their relation with clinical and structural magnetic resonance imaging
(MRI) measures.
Methods: RS functional magnetic resonance imaging (fMRI), clinical, and neuropsychological evaluation
were obtained from 215 MS patients and 98 healthy controls. Connectivity abnormalities and correlations
with clinical/neuropsychological/imaging measures were evaluated. We analyzed seed-voxel FC
with seven major hubs, producing one visual/sensory, one motor, two cognitive, one cerebellar, and two
subcortical networks.
Results: MS patients showed reduced network average RS FC versus controls in the default-mode network.
At regional level, a complex pattern of decreased and increased RS FC was found. Reduced RS FC
mainly involved sensorimotor, cognitive, thalamic, and cerebellar networks, whereas increased RS FC
involved visual/sensory and subcortical networks. Reduced RS FC correlated with T2 lesions. Reduced
thalamic RS FC correlated with better neuropsychological performance, whereas for all remaining networks
reduced FC correlated with more severe clinical/cognitive impairment.
Conclusion: Increased and decreased RS FC occurs in MS and contributes to a wide spectrum of clinical
manifestations. RS FC reduction is related to T2 lesions. Such a paradigm is inverted for the thalamic
network.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
resting state; functional connectivity; multiple sclerosis; clinical phenotype; cognitive impairment
Elenco autori:
M. Rocca, P. Valsasina, V. Leavitt, M. Rodegher, M. Radaelli, G. Riccitelli, V. Martinelli, F. Martinelli-Boneschi, A. Falini, G. Comi, M. Filippi
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