Data di Pubblicazione:
1979
Citazione:
Effect of aging on neurotransmitter receptor binding in rat and human brain / A. Maggi, M.J. Schmidt, B. Ghetti, S.J. Enna. - In: LIFE SCIENCES. - ISSN 0024-3205. - 24:4(1979), pp. 367-373.
Abstract:
β-Adrenergic and GABA receptor binding were measured in brain areas of rats 3 to 24 months of age. While GABA receptor binding was not significantly different across age in any area, β-adrenergic receptor binding was significantly reduced in the cerebellum and brain stem, but not cerebral cortex, of 24-month-old animals. The loss in β-adrenergic receptor binding does not correlate in a temporal fashion with the reported decrease in norepinephrine-stimulated cyclic AMP accumulation in the cerebellum which occurs as early as 12 months of age. An age-related reduction in β-adrenergic binding was also noted in human cerebellar tissue obtained at autopsy, suggesting that the cerebellar dysfunction seen with aging may be related to a loss of cerebellar neurons which receive noradrenergic input.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Adult; Aged; Alprenolol; Animals; Brain; Cerebellum; Cyclic AMP; Humans; In Vitro Techniques; Infant; Infant, Newborn; Male; Middle Aged; Neurotransmitter Agents; Norepinephrine; Rats; Receptors, Adrenergic, beta; Receptors, Cell Surface; Species Specificity; gamma-Aminobutyric Acid; Aging
Elenco autori:
A. Maggi, M.J. Schmidt, B. Ghetti, S.J. Enna
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