Data di Pubblicazione:
1980
Citazione:
Differential effects of antidepressant treatment on brain monoaminergic receptors / A. Maggi, D.C. U'Prichard, S.J. Enna. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 61:2(1980), pp. 91-98. [10.1016/0014-2999(80)90152-1]
Abstract:
Chronic (21 days) antidepressant administration to rats results in a decrease in both serotonin and beta-adrenergic, but not cholinergic muscarinic, receptor binding in selected brain regions, with the frontal cortex appearing to be somewhat more sensitive to this effect. Neither nisoxetine nor fluoxetine, potent and specific inhibitors of norepinephrine and serotonin uptake respectively, caused receptor binding changes after chronic administration, suggesting that inhibition of transmitter uptake, in itself, is insufficient to cause receptor subsensitivity. In vitro experiments indicated that antidepressants are relatively weak alpha 2-receptor blocking agents, but some are potent on the alpha 1-receptor system indicating that the norepinephrine releasing potency of some antidepressants may not be mediated by blockade of presynaptic autoreceptors.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Adrenergic receptors; Antidepressants; Cholinergic receptors; Serotonin receptors
Elenco autori:
A. Maggi, D.C. U'Prichard, S.J. Enna
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