Data di Pubblicazione:
1980
Citazione:
beta-Adrenergic regulation of alpha 2-adrenergic receptors in the central nervous system / A. Maggi, D.C. U'Prichard, S.J. Enna. - In: SCIENCE. - ISSN 0036-8075. - 207:4431(1980), pp. 645-647. [10.1126/science.6101510]
Abstract:
Incubation of rat cerebral cortical slices with the beta-adrenergic agonist isoproterenol causes an increase in alpha 2-adrenergic receptor binding in addition to a decrease in beta-adrenergic receptor binding. The effects are rapid and reversible, show a parallel time course, and are blocked by sotalol, a beta-adrenergic receptor antagonist. The beta-mediated regulation of alpha 2-receptor sensitivity at brain norepinephrine synapses may be a mechanism for the homeostatic control of central noradrenergic activity.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Adrenergic alpha-Agonists; Animals; Brain; Clonidine; Dihydroalprenolol; In Vitro Techniques; Isoproterenol; Male; Rats; Receptors, Adrenergic; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta; Sotalol
Elenco autori:
A. Maggi, D.C. U'Prichard, S.J. Enna
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