Hepatitis B immunity in teenagers vaccinated as infants : an Italian 17-year follow-up study
Articolo
Data di Pubblicazione:
2014
Citazione:
Hepatitis B immunity in teenagers vaccinated as infants : an Italian 17-year follow-up study / E. Spada, L. Romanò, M.E. Tosti, O. Zuccaro, S. Paladini, M. Chironna, R.C. Coppola, M. Cuccia, R. Mangione, F. Marrone, F.S. Negrone, A. Parlato, E. Zamparo, C.M. Zotti, A. Mele, A.R. Zanetti. - In: CLINICAL MICROBIOLOGY AND INFECTION. - ISSN 1198-743X. - 20:10(2014), pp. O680-O686. [10.1111/1469-0691.12591]
Abstract:
We assessed the persistence of hepatitis B surface antigen antibody (anti-HBs) and immune memory in a cohort of 571 teenagers vaccinated against hepatitis B as infants, 17 years earlier. Vaccinees were followed-up in 2003 and in 2010 (i.e. 10 years and 17 years after primary vaccination, respectively). When tested in 2003, 199 vaccinees (group A) had anti-HBs <10 mIU/mL and were boosted, 372 (group B) were not boosted because they had anti-HBs ≥10 mIU/mL (n = 344) or refused booster (n = 28) despite anti-HBs <10 mIU/mL. In 2010, 72.9% (416/571) of participants had anti-HBs ≥10 mIU/mL (67.3% in group A vs. 75.8% in group B; p 0.03). The geometric mean concentrations (GMCs) were similar in both groups. Between 2003 and 2010, anti-HBs concentrations in previously boosted individuals markedly declined with GMC dropping from 486 to 27.7 mIU/mL (p <0.001). Fifteen vaccinees showed a marked increase of antibody, possibly due to natural booster. In 2010, 96 individuals (37 of group A and 59 of group B) with anti-HBs <10 mIU/mL were boosted; all vaccinees of the former group and all but two of the latter had an anamnestic response. Post-booster GMC was higher in group B (895.6 vs. 492.2 mIU/mL; p 0.039). This finding shows that the immune memory for HBsAg persists beyond the time at which anti-HBs disappears, conferring long-term protection.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Booster; Hepatitis B; Immune memory; Long-term protection; Vaccination; Adolescent; Female; Follow-Up Studies; Hepatitis B; Hepatitis B Antibodies; Hepatitis B Surface Antigens; Hepatitis B Vaccines; Humans; Immunization, Secondary; Immunologic Memory; Infant; Italy; Male; Infectious Diseases
Elenco autori:
E. Spada, L. Romanò, M.E. Tosti, O. Zuccaro, S. Paladini, M. Chironna, R.C. Coppola, M. Cuccia, R. Mangione, F. Marrone, F.S. Negrone, A. Parlato, E. Zamparo, C.M. Zotti, A. Mele, A.R. Zanetti
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