Impairment of body mass reduction-associated activation of brown/beige adipose tissue in patients with type 2 diabetes mellitus
Articolo
Data di Pubblicazione:
2017
Citazione:
Impairment of body mass reduction-associated activation of brown/beige adipose tissue in patients with type 2 diabetes mellitus / S. Rodovalho, B. Rachid, J.C.D. Lima Júnior, S.V.D. Sande Lee, J. Morari, H. Carvalho, B. Amorim, A. Tincani, E. Chaim, J. Pareja, M. Saad, F. Folli, C. Ramos, B. Geloneze, L. Velloso. - In: INTERNATIONAL JOURNAL OF OBESITY. - ISSN 0307-0565. - 41:11(2017 Nov 01), pp. 1662-1668. [10.1038/ijo.2017.152]
Abstract:
BACKGROUNDS/OBJECTIVES:The activity of brown/beige adipose tissue is inversely proportional to body adiposity. Studies have shown that obese subjects submitted to distinct approaches aimed at reducing body mass present an increase of brown/beige adipose tissue activation. However, it is unknown if this beneficial effect of body mass reduction applies to patients with type 2 diabetes mellitus. In this study, we evaluated the impact of massive body mass reduction obtained as a consequence of bariatric surgery in the cold-induced activation of brown/beige adipose tissue in obese non-diabetic and obese diabetic subjects.
SUBJECTS/METHODS:This is an observational study. Fourteen obese non-diabetic, fourteen obese diabetic and eleven lean subjects were included in the study. All obese subjects were submitted to Roux-in-Y gastric bypass and measurements were performed before and eight months after surgery. Brown/beige adipose tissue was evaluated by (18F)-FDG PET/CT-scan and determination of signature transcript expression in specimens obtained in biopsies.
RESULTS:Before surgery, mean brown/beige adipose tissue activity and the expression of signature transcripts were similar between obese non-diabetic and obese diabetic groups. Eight months after surgery, body mass reduction was similar between the obese groups. Nevertheless, the activity of brown/beige adipose tissue was increased in obese non-diabetic and unchanged in obese diabetic subjects. This effect was correlated with a more pronounced improvement of insulin resistance, as evaluated by the hyperinsulinemic, euglycemic clamp, in obese non-diabetic subjects as compared with obese diabetic subjects.
CONCLUSIONS:Body mass reduction has a more efficient effect to induce the activation of brown/beige adipose tissue in non-diabetic than in diabetic subjects. This effect is accompanied by more pronounced insulin sensitivity and serine 473 phosphorylation of Akt in brown/beige adipose tissue of non-diabetic than in diabetic subjects.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
brown adipose tissue, obesity, type 2 diabete mellitus, PET, insulin resistance, gene expression, euglycemic clamp, Insulin signalling, akt, RYGB, bariatric surgery
Elenco autori:
S. Rodovalho, B. Rachid, J.C.D. Lima Júnior, S.V.D. Sande Lee, J. Morari, H. Carvalho, B. Amorim, A. Tincani, E. Chaim, J. Pareja, M. Saad, F. Folli, C. Ramos, B. Geloneze, L. Velloso
Link alla scheda completa: