Lack of evidence for post-vaccine onset of autoimmune/lymphoproliferative disorders, during a nine-month follow-up in multiply vaccinated Italian military
Articolo
Data di Pubblicazione:
2017
Citazione:
Lack of evidence for post-vaccine onset of autoimmune/lymphoproliferative disorders, during a nine-month follow-up in multiply vaccinated Italian military / C. Ferlito, V. Barnaba, S. Abrignani, M. Bombaci, A. Sette, J. Sidney, R. Biselli, E. Tomao, M.S. Cattaruzza, V. Germano, M.I. Biondo, G. Salerno, P. Lulli, S. Caporuscio, A.P. Diamanti, M. Falco, V. Biselli, P. Cardelli, A. Autore, E. Lucertini, D.P. De Cesare, M.S. Peragallo, F. Lista, C. Martire, S. Salemi, R. Nisini, R. D'Amelio. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - 181(2017 Aug), pp. 60-66. [10.1016/j.clim.2017.06.001]
Abstract:
Anecdotal case reports, amplified by mass media and internet-based opinion groups, have recently indicated vaccinations as possibly responsible for autoimmunity/lymphoproliferation development. Multiply vaccinated Italian military personnel (group 1, operating in Italy, group 2, operating in Lebanon) were followed-up for nine months to monitor possible post-vaccine autoimmunity/lymphoproliferation onset. No serious adverse event was noticed in both groups. Multivariate analysis of intergroup differences only showed a significant association between lymphocyte increase and tetanus/diphtheria vaccine administration. A significant post-vaccine decrease in autoantibody positivity was observed. Autoantibodies were also studied by microarray analysis of self-proteins in subjects exposed to ≥4 concurrent vaccinations, without observing significant difference among baseline and one and nine months post-vaccine. Moreover, HLA-A2 subjects have been analyzed for the possible CD8T-cell response to apoptotic self-epitopes, without observing significant difference between baseline and one month post-vaccine. Multiple vaccinations in young adults are safe and not associated to autoimmunity/lymphoproliferation onset during a nine-month-long follow-up.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Apoptotic self-epitopes; Autoimmunity; Lymphoproliferation; Microarray analysis; Military personnel; Vaccinations
Elenco autori:
C. Ferlito, V. Barnaba, S. Abrignani, M. Bombaci, A. Sette, J. Sidney, R. Biselli, E. Tomao, M.S. Cattaruzza, V. Germano, M.I. Biondo, G. Salerno, P. Lulli, S. Caporuscio, A.P. Diamanti, M. Falco, V. Biselli, P. Cardelli, A. Autore, E. Lucertini, D.P. De Cesare, M.S. Peragallo, F. Lista, C. Martire, S. Salemi, R. Nisini, R. D'Amelio
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