Role of Progesterone Receptor Membrane : Component 1in oogenesis and mammalian fertility

Infertility is a major problem affecting domestic mammals and declining fertility is damaging the profitability of dairy farms in Europe and worldwide. Since declining fertility in cattle is largely due to the poor quality of oocytes, research on the factors that affect oocyte quality is essential. Based on our preliminary data, we propose that Progesterone Receptor Membrane Component 1 (PGRMC1) is one of the key factors that regulate mammalian oocyte quality.