Data di Pubblicazione:
2015
Citazione:
Targeted diagnostic magnetic nanoparticles for medical imaging of pancreatic cancer / I. Rosenberger, A. Strauss, S. Dobiasch, C. Weis, S. Szanyi, L. Gil Iceta, E. Alonso, M. González Esparza, V. Gómez Vallejo, B. Szczupak, S. Plaza García, S. Mirzaei, L.L. Israel, S. Bianchessi, E. Scanziani, J. Lellouche, P. Knoll, J. Werner, K. Felix, L. Grenacher, T. Reese, J. Kreuter, M. Jiménez González. - In: JOURNAL OF CONTROLLED RELEASE. - ISSN 0168-3659. - 214(2015), pp. 7764.76-7764.84.
Abstract:
Abstract Highly aggressive cancer types such as pancreatic cancer possess a mortality rate of up to 80% within the first 6 months after diagnosis. To reduce this high mortality rate, more sensitive diagnostic tools allowing an early stage medical imaging of even very small tumours are needed. For this purpose, magnetic, biodegradable nanoparticles prepared using recombinant human serum albumin (rHSA) and incorporated iron oxide (maghemite, γ-Fe2O3) nanoparticles were developed. Galectin-1 has been chosen as target receptor as this protein is upregulated in pancreatic cancer and its precursor lesions but not in healthy pancreatic tissue nor in pancreatitis. Tissue plasminogen activator derived peptides (t-PA-ligands), that have a high affinity to galectin-1 have been chosen as target moieties and were covalently attached onto the nanoparticle surface. Improved targeting and imaging properties were shown in mice using single photon emission computed tomography-computer tomography (SPECT-CT), a handheld gamma camera, and magnetic resonance imaging (MRI).
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Handheld gamma camera; Maghemite; Magnetic resonance imaging (MRI); rHSA nanoparticles; Single photon emission computed tomography-computer tomography (SPECT-CT); t-PA-ligands to galectins; t-PApeptide1LAC; Animals; Cell Line, Tumor; Ferric Compounds; Galectin 1; Humans; Magnetic Resonance Imaging; Mice; Pancreatic Neoplasms; Radionuclide Imaging; Radiopharmaceuticals; Recombinant Proteins; Serum Albumin; Tissue Plasminogen Activator; Tomography, Emission-Computed, Single-Photon; Xenograft Model Antitumor Assays; Magnetics; Magnetite Nanoparticles; 3003
Elenco autori:
I. Rosenberger, A. Strauss, S. Dobiasch, C. Weis, S. Szanyi, L. Gil Iceta, E. Alonso, M. González Esparza, V. Gómez Vallejo, B. Szczupak, S. Plaza García, S. Mirzaei, L.L. Israel, S. Bianchessi, E. Scanziani, J. Lellouche, P. Knoll, J. Werner, K. Felix, L. Grenacher, T. Reese, J. Kreuter, M. Jiménez González
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