Data di Pubblicazione:
2016
Citazione:
Oestradiol synthesized by female neurons generates sex differences in neuritogenesis / I. Ruiz Palmero, A. Ortiz Rodriguez, R.C. Melcangi, D. Caruso, L.M. Garcia Segura, G.M. Rune, M. Arevalo. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 6:1(2016), p. 31891.31891.
Abstract:
Testosterone produced by the foetal testis is converted by male neurons to oestradiol, which masculinizes neuronal morphology. Female neurons are known to synthesize oestradiol in absence of exogenous testosterone. However, the role of neuronal oestradiol on the differentiation of foetal female neurons is unknown. Here we show that, due to endogenous neuronal oestradiol synthesis, female hippocampal neurons have higher expression of the neuritogenic protein Neurogenin 3 and enhanced neuritogenesis than males. Exogenous application of testosterone or its metabolite dihydrotestosterone increases Neurogenin 3 expression and promotes neuritogenesis in males, but reduces these parameters in females. Together our data indicate that gonadal-independent oestradiol synthesis by female neurons participates in the generation of sex differences in hippocampal neuronal development.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Multidisciplinary
Elenco autori:
I. Ruiz Palmero, A. Ortiz Rodriguez, R.C. Melcangi, D. Caruso, L.M. Garcia Segura, G.M. Rune, M. Arevalo
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