Data di Pubblicazione:
2016
Citazione:
Morc1 knockout evokes a depression-like phenotype in mice / M. Schmidt, C. Brandwein, A. Luoni, P. Sandrini, T. Calzoni, M. Deuschle, F. Cirulli, M.A. Riva, P. Gass. - In: BEHAVIOURAL BRAIN RESEARCH. - ISSN 0166-4328. - 296(2016), pp. 7-14. [10.1016/j.bbr.2015.08.005]
Abstract:
Morc1 gene has recently been identified by a DNA methylation and genome-wide association study as a candidate gene for major depressive disorder related to early life stress in rodents, primates and humans. So far, no transgenic animal model has been established to validate these findings on a behavioral level. In the present study, we examined the effects of a Morc1 loss of function mutation in female C57BL/6N mice on behavioral correlates of mood disorders like the Forced Swim Test, the Learned Helplessness Paradigm, O-Maze and Dark-Light-Box. We could show that Morc1(-/-) mice display increased depressive-like behavior whereas no behavioral abnormalities regarding locomotor activity or anxiety-like behavior were detectable. CORT plasma levels did not differ significantly between Morc1(-/-) mice and their wildtype littermates, yet - surprisingly - total Bdnf mRNA-levels in the hippocampus were up-regulated in Morc1(-/-) animals. Although further work would be clarifying, Morc1(-/-) mice seem to be a promising epigenetically validated mouse model for depression associated with early life stress.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Bdnf; Depression; Early life stress; Epigenetics; Morc1; Transgenic mice; Animals; Behavior, Animal; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Epigenesis, Genetic; Female; Hippocampus; Mice; Mice, Inbred C57BL; Mice, Knockout; Nuclear Proteins; Phenotype; RNA, Messenger; Up-Regulation; Behavioral Neuroscience
Elenco autori:
M. Schmidt, C. Brandwein, A. Luoni, P. Sandrini, T. Calzoni, M. Deuschle, F. Cirulli, M.A. Riva, P. Gass
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