Data di Pubblicazione:
2010
Citazione:
Novel pyrazole derivatives: Synthesis and evaluation of anti-angiogenic activity / M.S. Christodoulou, S. Liekens, K.M. Kasiotis, S.A. Haroutounian. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 18:12(2010), pp. 4338-4350. [10.1016/j.bmc.2010.04.076]
Abstract:
The synthesis of a series of novel trisubstituted pyrazole derivatives and their PIFA-mediated conversion to molecules bearing the fused pyrazolo[4,3-c]quinoline ring system is reported. The anti-angiogenic activity of these compounds was evaluated by using in vitro assays for endothelial cell proliferation and migration, and in the chicken chorioallantoic membrane (CAM) assay. Compounds containing the fused pyrazolo[4,3-c]quinoline motifs emerged as potent anti-angiogenic compounds, which also had the ability to inhibit the growth of human breast (MCF-7) and cervical (Hela) carcinoma cells in vitro. © 2010 Elsevier Ltd. All rights reserved.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Angiogenesis; CAM assay; Endothelial cell proliferation and migration; Inhibition of tumor growth; Pyrazole; Pyrazolo[4,3-c]quinoline; Angiogenesis Inhibitors; Animals; Cell Line, Tumor; Cell Movement; Chickens; Chorioallantoic Membrane; Cytostatic Agents; Endothelial Cells; Humans; Mice; Pyrazoles; Quinolines; 3003; Drug Discovery3003 Pharmaceutical Science; Organic Chemistry; Molecular Medicine; Molecular Biology; Clinical Biochemistry; Biochemistry; Medicine (all)
Elenco autori:
M.S. Christodoulou, S. Liekens, K.M. Kasiotis, S.A. Haroutounian
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