When membranes need an ESCRT : endosomal sorting and membrane remodelling in health and disease
Articolo
Data di Pubblicazione:
2016
Citazione:
When membranes need an ESCRT : endosomal sorting and membrane remodelling in health and disease / V. Alfred, T. Vaccari. - In: SWISS MEDICAL WEEKLY. - ISSN 1424-7860. - 146(2016), pp. w14347.1-w14347.14.
Abstract:
Originally discovered as regulators of cargo sorting during endosomal trafficking, ESCRT (endosomal sorting complexes required for transport) proteins are emerging as flexible machines that shape the behaviour of membranes throughout the cell. Deregulation of ESCRT activity is observed in neuro-degenerative diseases, virus infection and cancer. However, the mechanisms of pathogenesis involving ESCRTs have not yet fully come into focus. Here, we review the current knowledge of ESCRT function in health and disease and provide educated guesses for future research and focused therapeutic intervention.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Animals; Endosomes; Humans; Mutation; Neoplasms; Neurodegenerative Diseases; Nuclear Envelope; Virus Diseases; Endosomal Sorting Complexes Required for Transport
Elenco autori:
V. Alfred, T. Vaccari
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