T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP
Articolo
Data di Pubblicazione:
2017
Citazione:
T Follicular Helper Cells Promote a Beneficial Gut Ecosystem for Host Metabolic Homeostasis by Sensing Microbiota-Derived Extracellular ATP / L. Perruzza, G. Gargari, M. Proietti, B. Fosso, A.M. D'Erchia, C.E. Faliti, T. Rezzonico Jost, D. Scribano, L. Mauri, D. Colombo, G. Pellegrini, A. Moregola, C. Mooser, G. Pesole, M. Nicoletti, G.D. Norata, M.B. Geuking, K.D. Mccoy, S. Guglielmetti, F. Grassi. - In: CELL REPORTS. - ISSN 2211-1247. - 18:11(2017), pp. 2566-2575. [10.1016/j.celrep.2017.02.061]
Abstract:
The ATP-gated ionotropic P2X7 receptor regulates T follicular helper (Tfh) cell abundance in the Peyer's patches (PPs) of the small intestine; deletion of P2rx7, encoding for P2X7, in Tfh cells results in enhanced IgA secretion and binding to commensal bacteria. Here, we show that Tfh cell activity is important for generating a diverse bacterial community in the gut and that sensing of microbiota-derived extracellular ATP via P2X7 promotes the generation of a proficient gut ecosystem for metabolic homeostasis. The results of this study indicate that Tfh cells play a role in host-microbiota mutualism beyond protecting the intestinal mucosa by induction of affinity-matured IgA and suggest that extracellular ATP constitutes an inter-kingdom signaling molecule important for selecting a beneficial microbial community for the host via P2X7-mediated regulation of B cell help.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
ATP; IgA; metabolism; microbiota; P2rx7; T follicular helper cells; Biochemistry, Genetics and Molecular Biology (all)
Elenco autori:
L. Perruzza, G. Gargari, M. Proietti, B. Fosso, A.M. D'Erchia, C.E. Faliti, T. Rezzonico Jost, D. Scribano, L. Mauri, D. Colombo, G. Pellegrini, A. Moregola, C. Mooser, G. Pesole, M. Nicoletti, G.D. Norata, M.B. Geuking, K.D. Mccoy, S. Guglielmetti, F. Grassi
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