High-dose Ig VENA is well tolerated and efficacious in patients with multifocal motor neuropathy
Articolo
Data di Pubblicazione:
2017
Citazione:
High-dose Ig VENA is well tolerated and efficacious in patients with multifocal motor neuropathy / E. Nobile-Orazio, D. Cocito, C. Briani, R. Plasmati, A. Schenone, F. Gallia, I. Marjanovic, A. Lotti Suffredini. - In: NEUROLOGICAL SCIENCES. - ISSN 1590-3478. - 38:5(2017 May), pp. 899-902. [10.1007/s10072-017-2826-8]
Abstract:
Multifocal motor neuropathy (MMN) is a rare, chronic, motor neuropathy that progressively impairs physical functioning and quality of life. Randomised controlled trials have shown that high-dose intravenous immunoglobulin (IVIg) is superior to placebo in improving muscle strength and disability, but many patients require periodic infusions to maintain long-term improvement. This observational, multicentre, retrospective study investigated the efficacy and tolerability of human normal immunoglobulin (Ig VENA) at high intravenous infusion rates in 20 MMN patients (14 male, 6 female). Thirty days after the first infusion, there was an improvement of at least 1 point in two muscles compared to baseline on the Medical Research Council (MRC) scale and of 1 point in the ONLS (Overall Neuropathy Limitation Scale) scale in 15 patients (75%) and 10 patients (50%), respectively; 45% improved on both scales. At 6 months, 100% of 12 patients had improved on the MRC and 79% of 14 patients had improved on the ONLS scale; 83% improved on both scales. All reported adverse drug reactions (ADR) were mild, transient and possibly related to the study drug. Four patients (20%) reported ADRs, three reported headache and one fever. There were no serious or unexpected ADRs. By confirming that high-dose Ig VENA is efficacious and well tolerated, this study adds to the evidence base for IVIg in MMN and potentially increases clinicians’ and patients’ choice of therapy.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
multifocal motor neuropathy; Ig VENA; high dose; efficacy; tolerability; immunoglobulin therapy
Elenco autori:
E. Nobile-Orazio, D. Cocito, C. Briani, R. Plasmati, A. Schenone, F. Gallia, I. Marjanovic, A. Lotti Suffredini
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