Consumption of a bifidobacterium bifidum strain for 4 weeks modulates dominant intestinal bacterial taxa and fecal butyrate in healthy adults
Articolo
Data di Pubblicazione:
2016
Citazione:
Consumption of a bifidobacterium bifidum strain for 4 weeks modulates dominant intestinal bacterial taxa and fecal butyrate in healthy adults / G. Gargari, V. Taverniti, S. Balzaretti, C. Ferrario, C. Gardana, P. Simonetti, S. Guglielmetti. - In: APPLIED AND ENVIRONMENTAL MICROBIOLOGY. - ISSN 0099-2240. - 82:19(2016), pp. 5850-5859. [10.1128/AEM.01753-16]
Abstract:
Modulation of the intestinal microbial ecosystem (IME) is a useful target to establish probiotic efficacy in a healthy population. We conducted a randomized, double-blind, crossover, and placebo-controlled intervention study to determine the impact of Bifidobacterium bifidum strain Bb on the IME of adult healthy volunteers of both sexes. High-throughput 16S rRNA gene sequencing was used to characterize the fecal microbiota before and after 4 weeks of daily probiotic cell consumption. The intake of approximately one billion live B. bifidum cells affected the relative abundance of dominant taxa in the fecal microbiota and modulated fecal butyrate levels. Specifically, Prevotellaceae (P = 0.041) and Prevotella (P = 0.034) were significantly decreased, whereas Ruminococcaceae (P = 0.039) and Rikenellaceae (P = 0.010) were significantly increased. We also observed that the probiotic intervention modulated the fecal concentrations of butyrate in a manner dependent on the initial levels of short-chain fatty acids (SCFAs). In conclusion, our study demonstrates that a single daily administration of Bifidobacterium bifidum strain Bb can significantly modify the IME in healthy (not diseased) adults. These findings demonstrate the need to reassess the notion that probiotics do not influence the complex and stable IME of a healthy individual.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
human gut microbiota; inflammatory-bowel-disease; probiotic supplemetation; milk oligosaccharides; enteropypes; prevotella; intervention; metabolism; commensal; children
Elenco autori:
G. Gargari, V. Taverniti, S. Balzaretti, C. Ferrario, C. Gardana, P. Simonetti, S. Guglielmetti
Link alla scheda completa:
Link al Full Text: