Morphological and ultrastructural features of human islet grafts performed in diabetic nude mice
Articolo
Data di Pubblicazione:
2005
Citazione:
Morphological and ultrastructural features of human islet grafts performed in diabetic nude mice / G. Finzi, A. Davalli, C. Placidi, L. Usellini, S.L. Rosa, F. Folli, C. Capella. - In: ULTRASTRUCTURAL PATHOLOGY. - ISSN 0191-3123. - 29:6(2005), pp. 525-533. [10.1080/01913120500323563]
Abstract:
Islet transplantation is a new therapeutic approach to type 1 diabetes mellitus. However, in several patients insulin levels are not restored and the glycemic control is inadequate. To clarify the cause of graft failure, the authors investigated with light and electron microscopy some human islet grafts before and after transplantation under the kidney capsule of streptozotocin-induced diabetic nude mice. In isolated islets, both pre- and post-transplantation, the endocrine component was scarcely represented, the β/α cell ratio was reduced, and β cells showed degenerative aspects such as apoptosis, immature secretory granules, and amylin fibrils deposition. The authors conclude that islet graft failure may be due to an insufficent β cell mass related to their distress probably caused by anoxia and/or overstimulation.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
islet transplantation; beta cells degeneration; type 1 diabetes
Elenco autori:
G. Finzi, A. Davalli, C. Placidi, L. Usellini, S.L. Rosa, F. Folli, C. Capella
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