Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
Articolo
Data di Pubblicazione:
1990
Citazione:
Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase / S. Baekkeskov, H. Aanstoot, S. Christgai, A. Reetz, M. Solimena, M. Cascalho, F. Folli, H. Richter-Olesen, P. Camilli. - In: NATURE. - ISSN 0028-0836. - 347:6289(1990), pp. 151-156.
Abstract:
The pancreatic islet β-cell autoantigen of relative molecular mass 64,000 (64K), which is a major target of autoantibodies associated with the development of insulin-dependent diabetes mel-litus (IDDM) has been identified as glutamic acid decarboxylase, the biosynthesizing enzyme of the inhibitory neurotransmitter GABA (γ-aminobutyric acid). Pancreatic β cells and a subpopulation of central nervous system neurons express high levels of this enzyme. Autoantibodies against glutamic acid decarboxylase with a higher titre and increased epitope recognition compared with those usually associated with IDDM are found in stiff-man syndrome, a rare neurological disorder characterized by a high coincidence with IDDM.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Medicine (all); Multidisciplinary
Elenco autori:
S. Baekkeskov, H. Aanstoot, S. Christgai, A. Reetz, M. Solimena, M. Cascalho, F. Folli, H. Richter-Olesen, P. Camilli
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