Atopy patch tests are useful to predict oral tolerance in children with gastrointestinal symptoms related to non-IgE-mediated cow's milk allergy
Articolo
Data di Pubblicazione:
2013
Citazione:
Atopy patch tests are useful to predict oral tolerance in children with gastrointestinal symptoms related to non-IgE-mediated cow's milk allergy / R. Nocerino, V. Granata, M. Di Costanzo, V. Pezzella, L. Leone, A. Passariello, G. Terrin, R. Troncone, R. Berni Canani. - In: ALLERGY. - ISSN 0105-4538. - 68:2(2013 Feb), pp. 246-248. [10.1111/all.12071]
Abstract:
Atopy patch tests (APTs) have been proposed for the diagnostic approach in children with non-IgE-mediated cow's milk allergy and gastrointestinal symptoms. We aimed to investigate the benefit of APTs in predicting oral tolerance in these patients. We prospectively evaluated 172 subjects with a sure diagnosis of non-IgE-mediated CMA and gastrointestinal symptoms (97 boys, 56.4%; age, 6.37 m; range, 2-12 m). At diagnosis, 113/172 (65.7%) children had positive APTs to cow's milk proteins (CMP). After 12 months of exclusion, diet APTs were repeated immediately before OFC. APTs significantly correlated (P < 0.001) with the OFC outcome (r 0.579). Diagnostic accuracy was sensitivity of 67.95%, specificity of 88.3%, PPV of 82.81%, NPV of 76.85%, and a +LR of 5.80. APTs are a valuable tool in the follow-up of children with non-IgE-mediated CMA-related gastrointestinal symptoms by contributing in determining whether an OFC can safely be undertaken.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
cow's milk protein; food allergy; oral food challenge; oral tolerance; pediatric patients
Elenco autori:
R. Nocerino, V. Granata, M. Di Costanzo, V. Pezzella, L. Leone, A. Passariello, G. Terrin, R. Troncone, R. Berni Canani
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