Continuous-flow stereoselective synthesis in microreactors : nucleophilic additions to nitrostyrenes organocatalyzed by a chiral bifunctional catalyst
Articolo
Data di Pubblicazione:
2015
Citazione:
Continuous-flow stereoselective synthesis in microreactors : nucleophilic additions to nitrostyrenes organocatalyzed by a chiral bifunctional catalyst / S. Rossi, M. Benaglia, A. Puglisi, C. De Filippo, M. Maggini. - In: JOURNAL OF FLOW CHEMISTRY. - ISSN 2062-249X. - 5:1(2015), pp. 17-21.
Abstract:
Metal-free stereoselective additions of activated nucleophiles to β-nitrostyrenes were investigated under continuous-flow conditions in microreactors, in the presence of a chiral bifunctional catalyst. Optimization of the experimental setup gave excellent enantioselectivities (up to 85% e.e.) and higher productivities if compared to the flask syntheses. The potential of this flow chemistry approach was demonstrated by the successful synthesis of an advanced intermediate for the preparation of the GABAB receptor agonist Baclofen.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
bifunctional catalyst; flow chemistry; microreactors; nitrostyrenes; organocatalysis; Chemistry (miscellaneous); Fluid Flow and Transfer Processes; Organic Chemistry
Elenco autori:
S. Rossi, M. Benaglia, A. Puglisi, C. De Filippo, M. Maggini
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