Data di Pubblicazione:
2015
Citazione:
Lessons learnt over two decades of vaccination against hepatitis B in Italy / L. Romanò, C. Galli, A.R. Zanetti. - In: JOURNAL OF PREVENTIVE MEDICINE AND HYGIENE. - ISSN 2421-4248. - 56:1(2015 Jun), pp. 12-14. [10.15167/2421-4248/jpmh2015.56.1.469]
Abstract:
This article reviews topics covered and discussed at the Meeting: "Vaccini e vaccinazioni. Migliorare l'oggi e preparare il domani", held in Genoa, Italy, on 12 September 2014. Data presented at the meeting, clearly showed that: 1) hepatitis B vaccination can confer long-term protection and there is no need for booster in immunocompetent vaccinees; 2) vaccination is highly effective in protecting population from clinical acute or chronic HBV infections, including hepatocellular carcinoma; 3) children vaccinated as infants with hexavalent vaccines maintain immunological memory 5 years after priming, but further studies are needed to assess whether immunity persists during the adolescence and adulthood when risk of exposure to HBV becomes higher; 4) the emergence of vaccine-escape mutants and Pol-gene mutants during antiviral therapy - which can result in changes in the S-gene - is of some concern, but at present there is no evidence that such mutants may pose a threat to the established programs of vaccination.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
HBV mutants; Hepatitis B; Vaccination
Elenco autori:
L. Romanò, C. Galli, A.R. Zanetti
Link alla scheda completa: