Diet in children with phenylketonuria and risk of cardiovascular disease : A narrative overview
Articolo
Data di Pubblicazione:
2016
Citazione:
Diet in children with phenylketonuria and risk of cardiovascular disease : A narrative overview / E. Verduci, G. Banderali, F. Moretti, C. Lassandro, G. Cefalo, G. Radaelli, E. Salvatici, M. Giovannini. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 26:3(2016 Mar), pp. 171-177.
Abstract:
Aims: The aim of this paper is to review the possible relationship of restricted phenylalanine (Phe) diet, a diet primarily comprising low-protein foods and Phe-free protein substitutes, with major cardiovascular risk factors (overweight/obesity, blood lipid profile, plasma levels of homocysteine, adiponectin and free asymmetric dimethylarginine (ADMA), oxidative stress and blood pressure) in PKU children. Data synthesis: In PKU children compliant with diet, blood total cholesterol, low-density lipoprotein cholesterol (LDL-C), plasma ADMA levels and diastolic pressure were reported to be lower and plasma adiponectin levels to be higher compared to healthy controls. No difference was observed in overweight prevalence and in high-density lipoprotein cholesterol (HDL-C) levels. Inconsistent results were found for plasma homocysteine levels and antioxidant status. Conclusions: PKU children compliant with diet seem to display non-different cardiovascular risks compared with the healthy population. Well-designed longitudinal studies are required to clarify the potential underlying mechanisms associated with PKU and cardiovascular risk factors.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
cardiovascular risk; lipid profile; nutrition; obesity; phenylketonuria; pku diet; medicine (miscellaneous); nutrition and dietetics; endocrinology, diabetes and metabolism; cardiology and cardiovascular medicine
Elenco autori:
E. Verduci, G. Banderali, F. Moretti, C. Lassandro, G. Cefalo, G. Radaelli, E. Salvatici, M. Giovannini
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