Molsidomine attenuates N-omega-nitro-L-argininemethylester-induced deficits in a memory task in the rat
Articolo
Data di Pubblicazione:
2002
Citazione:
Molsidomine attenuates N-omega-nitro-L-argininemethylester-induced deficits in a memory task in the rat / N. Pitsikas, A. Rigamonti, S. Cella, E. Müller. - In: EUROPEAN JOURNAL OF PHARMACOLOGY. - ISSN 0014-2999. - 451:1(2002), pp. 82-86. [10.1016/S0014-2999(02)02236-7]
Abstract:
The present study was designed to investigate the role of nitric oxide (NO) on recognition memory in the rat. For this purpose, the effects on memory exerted by post-training administration of the NO synthase (NOS) inhibitor N-omega-nitro-L-argininemethylester (L-NAME) and the NO donor molsidomine were assessed by using the object recognition task. In a first dose-response study, L-NAME, at 30 but not at 10 mg/kg impaired the animals' performance, whereas at 60 mg/kg, it induced side-effects. Molsidomine, 4 mg/kg, antagonized the L-NAME-induced performance deficits. These results indicate that NO is involved in post-training memory processes.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
nitric oxide (NO); L-NAME (N-omega-nitro-L-argininemethylester); molsidomine; recognition memory, rat
Elenco autori:
N. Pitsikas, A. Rigamonti, S. Cella, E. Müller
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