Effect of enhancement of cholinergic tone on the growth hormone response to acute hyperglycemia or thyrotropin-releasing hormone in dogs
Articolo
Data di Pubblicazione:
1992
Citazione:
Effect of enhancement of cholinergic tone on the growth hormone response to acute hyperglycemia or thyrotropin-releasing hormone in dogs / V. Arce, S. Cella, V. Locatelli, E. Müller. - In: JOURNAL OF NEUROENDOCRINOLOGY. - ISSN 0953-8194. - 4:1(1992), pp. 63-66.
Abstract:
The effect of enhancement of cholinergic tone by pyridostigmine on the growth hormone (GH) response to thyrotropin-releasing hormone (TRH) or glucose-induced acute hyperglycaemia was tested in six adult unanaesthetized beagle dogs. Both TRH (5-mu-g/kg iv) and glucose (2 g/kg orally) did not significantly alter baseline GH levels but reduced the GH response to GH-releasing hormone (GHRH) (2-mu-g/kg iv), although this effect was more clear-cut with TRH than with glucose. Pretreatment with pyridostigmine (2 mg/kg orally) counteracted the inhibitory effect of hyperglycaemia on the GHRH-induced GH release, but had no effect on the inhibition induced by TRH. In summary, these results indicate that: 1) acute hyperglycaemia and TRH play an inhibitory role on GHRH-stimulated GH secretion in dogs; 2) the inhibitory effect of acute hyperglycaemia is mediated via hypothalamic cholinergic neurotransmission, whereas other neurotransmitter pathways would be involved in the effect of TRH.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
growth hormone; growth hormone-releasing hormone; somatostatin; thyrotropin-releasing hormone; glucose
Elenco autori:
V. Arce, S. Cella, V. Locatelli, E. Müller
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