Data di Pubblicazione:
2016
Citazione:
Effect of intravenous l-carnitine in Chinese patients with chronic heart failure / Z.C. Jing, B.X. Wu, J.J. Peng, X.L. Li, L. Pan, S.P. Zhao, D.Y. Li, Z.X. Yu, J.B. Gong, Q.Y. Zhao, J.N. Cao, G.T. Sheng, J. Li, B.J.M.X.Y. Li, S. Jiang, C.F. Liang, E. Salvi, V. Carubelli. - In: EUROPEAN HEART JOURNAL SUPPLEMENTS. - ISSN 1554-2815. - 18:A(2016), pp. A27-A36. [10.1093/eurheartj/suw008]
Abstract:
Chronic heart failure (CHF) may be associated with an energy deficit in cardiac muscle. As levo-carnitine (LC) is involved in the production of myocardial energy, it is hypothesized that LC supplementation may ameliorate CHF symptoms. This multicentre, randomized, double-blind, and placebo-controlled study included 265 patients with CHF. Patients were randomized to receive either LC or placebo, twice a day. Endpoints were measured after 7 days of treatment. Primary endpoint was a reduction of at least one NYHA class. Secondary endpoints were changes in 6-min walk distance (6-MWD) compared with baseline, either alone or in combination with NYHA class decrease, left ventricular ejection fraction, and NT-proBNP level, together with adverse events. The primary endpoint was reached in 60.9% of patients treated with LC, compared with only 44.7% of the placebo group (P = 0.012). Among the secondary endpoints, 6-MWD, alone or in combination with NYHA class, improved significantly in the LC group compared with placebo (P = 0.0497 and P = 0.003, respectively). l-Carnitine was well tolerated. The lowest baseline values of plasma-free carnitine were observed in patients with NYHA classes III and IV where the effect of LC supplementation was greatest (P = 0.002). Treatment with LC significantly improved CHF symptoms in Chinese patients, probably by correcting a status of carnitine insufficiency.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Chinese patients; Chronic heart failure; Plasma carnitine; Carnitine supplementation; NYHA class; 6-min walk distance
Elenco autori:
Z.C. Jing, B.X. Wu, J.J. Peng, X.L. Li, L. Pan, S.P. Zhao, D.Y. Li, Z.X. Yu, J.B. Gong, Q.Y. Zhao, J.N. Cao, G.T. Sheng, J. Li, B.J.M.X.Y. Li, S. Jiang, C.F. Liang, E. Salvi, V. Carubelli
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