Morphologic, immunologic, and cytogenetic characteristics of secondary acute unclassifiable leukemia in Hodgkin's disease
Articolo
Data di Pubblicazione:
1988
Citazione:
Morphologic, immunologic, and cytogenetic characteristics of secondary acute unclassifiable leukemia in Hodgkin's disease / A. Orazi, G. Cattoretti, G. Sozzi, M. Miozzo, N. Polli, D. Delia, S. Viviani, E. Negretti, G. Della Porta, F. Rilke. - In: TUMORI. - ISSN 0300-8916. - 74:4(1988 Aug), pp. 439-450.
Abstract:
Blast cells from five cases of secondary unclassifiable leukemia following therapy for Hodgkin's disease were studied by cytochemical, immunological and cytogenetic analyses. Cytochemical and immunological reactivity were in accordance with poorly differentiated, myeloid blasts. The four cases in which karyotype analysis was performed showed specific chromosomal abnormalities. No evidence of multiple lineage involvement was found. Problems in classifying these cases of secondary ANLL were due to the high grade of undifferentiation of the blast cells. Their low cytochemical reactivity with markers of myeloid differentiation was similar to what may be observed in patients with acute undifferentiated leukemia or with chronic myeloid leukemia in blast crisis.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cancer Research
Elenco autori:
A. Orazi, G. Cattoretti, G. Sozzi, M. Miozzo, N. Polli, D. Delia, S. Viviani, E. Negretti, G. Della Porta, F. Rilke
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