The human tropomyosin gene involved in the generation of the TRK oncogene maps to chromosome 1q31
Articolo
Data di Pubblicazione:
1991
Citazione:
The human tropomyosin gene involved in the generation of the TRK oncogene maps to chromosome 1q31 / P. Radice, G. Sozzi, M. Miozzo, V. De Benedetti, T. Cariani, I. Bongarzone, N.K. Spurr, M.A. Pierotti, G. Della Porta. - In: ONCOGENE. - ISSN 0950-9232. - 6:11(1991 Dec), pp. 2145-2148.
Abstract:
The chromosomal localization of hTMnm, a gene coding for a cytoskeletal tropomyosin non-muscle isoform involved in the activation of the TRK proto-oncogene in various human tumors, was determined by Southern blot analysis of a panel of human-rodent somatic cell hybrids. Using as a probe an Alu-free intronic fragment related to the tropomyosin sequence fused to the TRK tyrosine kinase domain, the hTMnm gene was assigned to the long arm of chromosome 1. Subsequently, in situ hybridization of the same probe to human metaphase chromosomes localized the hTMnm gene to 1q31. Since we have recently assigned the TRK locus to chromosome 1q32-q41, the generation of the hybrid transforming sequence tropomyosin-TRK may be due to an intrachromosomal rearrangement of the long arm of chromosome 1.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Cancer Research; Genetics; Molecular Biology
Elenco autori:
P. Radice, G. Sozzi, M. Miozzo, V. De Benedetti, T. Cariani, I. Bongarzone, N.K. Spurr, M.A. Pierotti, G. Della Porta
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