Data di Pubblicazione:
1996
Citazione:
Mapping of a putative tumor suppressor locus to proximal 7p in Wilms tumors / M. Miozzo, D. Perotti, F. Minoletti, P. Mondini, S. Pilotti, R. Luksch, F. Fossati-Bellani, M.A. Pierotti, G. Sozzi, P. Radice. - In: GENOMICS. - ISSN 0888-7543. - 37:3(1996), pp. 310-315. [10.1006/geno.1996.0565]
Abstract:
Different findings suggest that alterations of chromosome 7 genes play a role in the development of Wilms tumors. To define the positions of these genes, we have accomplished a combined cytogenetic and molecular study on 11 sporadic Wilms tumors. In one case, where both chromosomes 7 were rearranged, the karyotypic picture was consistent with the presence of a tumor suppressor gene at 7p15. To test this hypothesis, a loss of heterozygosity analysis was performed using microsatellite markers. This revealed a common region of allele losses mapped to the proximal short arm of chromosome 7 and defined the position of the gene(s) involved in Wilms tumors within an interval of approximately 25 cM.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Chromosome Mapping; Chromosomes, Human, Pair 7; Female; Gene Deletion; Heterozygote; Humans; Karyotyping; Kidney Neoplasms; Male; Microsatellite Repeats; Wilms Tumor; Genes, Tumor Suppressor; Genetics
Elenco autori:
M. Miozzo, D. Perotti, F. Minoletti, P. Mondini, S. Pilotti, R. Luksch, F. Fossati-Bellani, M.A. Pierotti, G. Sozzi, P. Radice
Link alla scheda completa: