Normalization of multiple hemostatic abnormalities in uremic type 1 diabetic patients after kidney-pancreas transplantation
Articolo
Data di Pubblicazione:
2004
Citazione:
Normalization of multiple hemostatic abnormalities in uremic type 1 diabetic patients after kidney-pancreas transplantation / P. Fiorina, F. Folli, A. D'Angelo, G. Finzi, F. Pellegatta, V. Guzzi, C. Fedeli, P.D. Valle, L. Usellini, C. Placidi, F. Bifari, D. Belloni, E. Ferrero, C. Capella, A. Secchi. - In: DIABETES. - ISSN 0012-1797. - 53:9(2004), pp. 2291-2300.
Abstract:
To evaluate the effects of kidney-pancreas transplantation on hemostatic abnormalities in uremic type 1 diabetic patients, we conducted a cross-sectional study involving 12 type 1 diabetic patients, 30 uremic type I diabetic patients, 27 uremic type I diabetic patients who had a kidney-pancreas transplant, 12 uremic type 1 diabetic patients who had a kidney-alone transplant, and 13 healthy control subjects. We evaluated platelet and clotting system. Platelets in the group of uremic type 1 diabetic patients were significantly larger than platelets in the other groups. Resting calcium levels were significantly higher in the uremic type 1 diabetic patients and uremic type 1 diabetic patients who had a kidney-alone transplant than in the type 1 diabetic patients who had a kidney-pancreas transplant and control subjects. CD41 expression was significantly reduced in platelets from the uremic type I diabetic patients compared with the other groups. Levels of hypercoagulability markers in the type 1 diabetic patients who had a kidney-pancreas transplant and, to a lesser extent, the uremic type I diabetic patients who had a kidney-alone transplant but not the uremic type 1 diabetic patients were similar to those of the control subjects. A reduction in natural anticoagulants was evident in the uremic type 1 diabetic patients, whereas near-normal values were observed in the type I diabetic patients who had a kidney-pancreas transplant and uremic type I diabetic patients who had a kidney-alone transplant. Hemostatic abnormalities were not observed in type 1 diabetic patients who had a kidney-pancreas transplant. This finding might explain the lower cardiovascular death rate observed in type 1 diabetic patients who had a kidney-pancreas transplant compared with uremic type 1 diabetic patients who had a kidney-alone transplant or uremic type I diabetic patients.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
platelet calcium homeostasis; chronic dialysis patients; stage renal-failure; activated platelets; islet transplantation; thrombin-receptor; risk-factors; mellitus; disease; IDDM
Elenco autori:
P. Fiorina, F. Folli, A. D'Angelo, G. Finzi, F. Pellegatta, V. Guzzi, C. Fedeli, P.D. Valle, L. Usellini, C. Placidi, F. Bifari, D. Belloni, E. Ferrero, C. Capella, A. Secchi
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