Data di Pubblicazione:
2009
Citazione:
Evaluating endothelial function of the common carotid artery: an in vivo human model / S. Mazzucco, F. Bifari, M. Trombetta, G.C. Guidi, M. Mazzi, G.P. Anzola, N. Rizzuto, R. Bonadonna. - In: NMCD. NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES. - ISSN 0939-4753. - 19:3(2009 Mar), pp. 205-210. [10.1016/j.numecd.2008.06.010]
Abstract:
Background and aims: Flow mediated dilation (FMD) of peripheral conduit arteries is a well-established tool. to evaluate endothelial function. The aims of this study are to apply the FMD model to cerebral circulation by using acetazolamide (ACZ)-induced intracranial vasodilation as a stimulus to increase common carotid artery (CCA) diameter in response to a Local increase of blood flow velocity (BFV).
Methods and results: In 15 healthy subjects, CCA end-diastolic diameter and BFV, middle cerebral artery (MCA) BFV and mean arterial blood pressure (MBP) were measured at basal conditions, after an intravenous bolus of 1 g ACZ, and after placebo (saline) sublingual administration at the 15th and 20th minute. In a separate session, the same parameters were evaluated after placebo (saline) infusion instead of ACZ and after 10 mu g/m(2) bs and 300 mu g of glyceryl trinitrate (GTN), administered sublingually, at the 15th and 20th minute, respectively. After ACZ bolus, there was a 35% maximal MCA mean BFV increment (14th minute), together with a 22% increase of mean CCA end-diastolic BFV and a CCA diameter increment of 3.9% at the 3rd minute (p = 0.024). There were no MBP significant variations up to the 15th minute (p = 0.35). After GTN administration, there was a significant increment in CCA diameter (p < 0.00001).
Conclusions: ACZ causes a detectable CCA dilation in healthy individuals concomitantly with an increase in BFV. Upon demonstration that this phenomenon is endothelium dependent, this experimental model might become a valuable tool. to assess endothelial function in the carotid artery.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Acetazolamide; Carotid ultrasound; Endothelial function; Flow-mediated dilation; Transcranial Doppler
Elenco autori:
S. Mazzucco, F. Bifari, M. Trombetta, G.C. Guidi, M. Mazzi, G.P. Anzola, N. Rizzuto, R. Bonadonna
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