Incremental utility of prognostic variables at discharge for risk prediction in hospitalized patients with acutely decompensated chronic heart failure
Articolo
Data di Pubblicazione:
2016
Citazione:
Incremental utility of prognostic variables at discharge for risk prediction in hospitalized patients with acutely decompensated chronic heart failure / D. Scrutinio, A. Passantino, P. Guida, E. Ammirati, F. Oliva, R. Lagioia, S. Sarzi Braga, P. Agostoni, M. Frigerio. - In: HEART & LUNG. - ISSN 0147-9563. - 45:3(2016 May), pp. 212-219.
Abstract:
Objectives: To assess the incremental prognostic utility of discharge serum creatinine (SCr), systolic blood pressure (SBP), and NT-proBNP and sodium concentrations in hospitalized patients with acutely decompensated chronic heart failure. Background: Whether key prognostic variables at discharge provide incremental prognostic information beyond that provided by a model based on admission variables (referent) remains incompletely defined. Methods: The primary outcome was a composite of death, urgent heart transplantation, or ventricular assist device implantation at 1 year. The gain in predictive performance was assessed using C index, Bayesian Information Criterion, and Net Reclassification Improvement. Results: The best fit was obtained when discharge NT-proBNP was added to the referent model. No interaction between admission and discharge NT-proBNP was found. Discharge SCr, SBP, and sodium did not improve goodness-of-fit. Conclusions: Admission and discharge NT-proBNP provide complementary and independent prognostic information; as such, they should be taken into account concurrently.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Acutely decompensated chronic heart failure; Admission N-terminal Pro-B-Type natriuretic peptide; Prognosis; Discharge N-terminal Pro-B-Type natriuretic peptide; Risk stratification
Elenco autori:
D. Scrutinio, A. Passantino, P. Guida, E. Ammirati, F. Oliva, R. Lagioia, S. Sarzi Braga, P. Agostoni, M. Frigerio
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