Effects of hypobaric hypoxia exposure at high altitude on left ventricular twist in healthy subjects : data from HIGHCARE study on Mount Everest
Articolo
Data di Pubblicazione:
2016
Citazione:
Effects of hypobaric hypoxia exposure at high altitude on left ventricular twist in healthy subjects : data from HIGHCARE study on Mount Everest / G. Osculati, M. Revera, G. Branzi, A. Faini, G. Malfatto, G. Bilo, A. Giuliano, F. Gregorini, F. Ciambellotti, C. Lombardi, P. Agostoni, G. Mancia, G. Parati. - In: EUROPEAN HEART JOURNAL. CARDIOVASCULAR IMAGING. - ISSN 2047-2404. - 17:6(2016 Jun), pp. 635-643. [10.1093/ehjci/jev166]
Abstract:
Previous studies investigating the effect of hypoxia on left ventricle focused on its global function, an approach that may not detect a selective dysfunction of subendocardial layers that are most sensitive to an inadequate oxygen supply. In the HIGHCARE study, aimed at exploring the effects of high altitude hypoxia on multiple biological variables and their modulation by an angiotensin receptor blocker, we addressed the effects of hypobaric hypoxia on both systolic and diastolic left ventricular geometry and function, focusing on echocardiographic assessment of left ventricle twist to indirectly examine subendocardial left ventricular systolic function.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
high altitude; hypobaric hypoxia; left ventricular twist and torsion; subendocardial left ventricle function
Elenco autori:
G. Osculati, M. Revera, G. Branzi, A. Faini, G. Malfatto, G. Bilo, A. Giuliano, F. Gregorini, F. Ciambellotti, C. Lombardi, P. Agostoni, G. Mancia, G. Parati
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