SORL1 gene is associated with the conversion from mild cognitive impairment to Alzheimer's disease
Articolo
Data di Pubblicazione:
2015
Citazione:
SORL1 gene is associated with the conversion from mild cognitive impairment to Alzheimer's disease / P. Piscopo, G. Tosto, C. Belli, G. Talarico, D. Galimberti, M. Gasparini, M. Canevelli, A. Poleggi, A. Crestini, D. Albani, G. Forloni, U. Lucca, P. Quadri, M. Tettamanti, C. Fenoglio, E. Scarpini, B. GIUSEPPE EUGENIO, N. Vanacore, A. Confaloni. - In: JOURNAL OF ALZHEIMER'S DISEASE. - ISSN 1387-2877. - 46:3(2015), pp. 771-776. [10.3233/JAD-141551]
Abstract:
Several studies have established the sortilin-related receptor gene (SORL1) as a susceptibility locus for Alzheimer's disease (AD). Single nucleotide polymorphisms of SORL1 reported in literature as being associated with AD were investigated in an Italian case-control data set, and their role as a risk factor of conversion to AD was studied in an independent sample of subjects diagnosed with mild cognitive impairment (MCI) at baseline. rs641120, rs2070045, and rs1010159 were genotyped in 734 subjects diagnosed with AD (n = 338) and MCI (n = 181) and in healthy controls (n = 215). Our results confirmed the association between rs641120 andAD(p = 0.01). In theMCIcohort, rs1010159was associated with conversion toAD(HR = 1.56, p = 0.002). Taken together, these findings confirm that SORL1 is associated with AD and might be a potential tool for identifying MCI subjects at high risk of conversion to AD.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
Alzheimer's disease; mild cognitive impairment; single nucleotide polymorphisms; SORL1; Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cohort Studies; Disease Progression; Female; Genetic Association Studies; Genotype; Humans; Italy; LDL-Receptor Related Proteins; Male; Membrane Transport Proteins; Middle Aged; Mild Cognitive Impairment; Neuropsychological Tests; Polymorphism, Single Nucleotide; Proportional Hazards Models; Psychiatric Status Rating Scales; Psychiatry and Mental Health; Geriatrics and Gerontology; Clinical Psychology; Medicine (all)
Elenco autori:
P. Piscopo, G. Tosto, C. Belli, G. Talarico, D. Galimberti, M. Gasparini, M. Canevelli, A. Poleggi, A. Crestini, D. Albani, G. Forloni, U. Lucca, P. Quadri, M. Tettamanti, C. Fenoglio, E. Scarpini, B. GIUSEPPE EUGENIO, N. Vanacore, A. Confaloni
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