Data di Pubblicazione:
2016
Citazione:
Perinatal major depression biomarkers: a systematic review / M. Serati, M. Redaelli, M. Buoli, A.C. Altamura. - In: JOURNAL OF AFFECTIVE DISORDERS. - ISSN 0165-0327. - 193(2016 Mar), pp. 391-404. [10.1016/j.jad.2016.01.027]
Abstract:
Postpartum depression, now termed perinatal depression by the DSM-5, is a clinically relevant disorder reaching 15% of incidence. Although it is quite frequent and associated with high social dysfunction, only recently its underpinning biological pathways have been explored, while multiple and concomitant risk factors have been identified (e.g. psychosocial stress). Peripartum depression usually has its onset during the third trimester of pregnancy or in the postpartum, being one of the most common medical complications in new mothers. Purpose of the present review is to summarize the state of art of biological biomarkers involved in the pathogenesis of perinatal depression, in view of the fact that suboptimal prenatal milieu can induce permanent damage in subsequent offspring life and have a negative impact on mother-child relationship. Furthermore, parents' biological changes due to medical/psychiatric disorders or stress exposure could influence offspring life: a concept known as 'intergenerational transmission', acting by variations into gametes and the gestational uterine environment. Given the evidence that perinatal mental disorders involve risks for the mother and offspring, the search for reliable biomarkers in high-risk mothers actually represents a medical priority to prevent perinatal depression.
Tipologia IRIS:
01 - Articolo su periodico
Keywords:
corticotropin-releasing hormone; potential diagnostic markers; African-American women; postpartum depression; late pregnancy; risk-factors; vitamin-D; postnatal depression; docosahexaenoic acid; gene polymorphisms
Elenco autori:
M. Serati, M. Redaelli, M. Buoli, A.C. Altamura
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